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Scientific studies have shown that knockdown of ULK inhibits autophagosome development. Mice with defects in ULK1 and ULK2 die inside 24 h following delivery [41]. When ULK1 is expressed in mammalian cells, ULK2 just isn't necessary for autophagy. Even so, when ULK1 expression is inhibited, ULK2 can compensate for your purpose of ULK1 in regulating
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